Informatie over | Engels woord DOWNREGULATE

Voorbeelden van het gebruik van DOWNREGULATE in een zin

• Insulin resistance (IR) is a pathological condition in which cells in insulin-sensitive tissues in the body fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia.
• It, combined with the Ras pathway, downregulate cyclin D1, a cyclin-dependent kinase, if they are not stimulated by the presence of mitogens.
• For example, some Antarctic diatoms downregulate glycolysis in environments with low to no irradiance, while upregulating other mitochondrial metabolic pathways, including the Entner−Doudoroff pathway which provides the TCA cycle (an important component in cellular respiration) with pyruvate when pyruvate cannot be obtained via photosynthesis.
• As cell density increases and the culture becomes confluent, they initiate cell cycle arrest and downregulate proliferation and mitogen signaling pathways regardless of external factors or cellular metabolism.
• One route to upregulate a gene is for the ATF to recruit proteins that loosen the DNA wrapping around histones allowing RNA polymerase to bind and transcribe the gene; likewise, compacting the DNA would downregulate gene expression by inhibiting RNA polymerase from binding.
• Treg expression of CTLA-4 can effectively downregulate both CD80 and CD86 on APCs, suppress the immune response and lead to increased anergy.
• Inflammation mediators such as prostaglandin E2 (PGE2), IL-18 and other inflammasome components are known to downregulate IL-22BP production, on the other hand, the presence of retinoic acid, metabolite of vitamin A, is known to induce IL-22BP secretion.
• Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6 coreceptor to downregulate GSK3beta (GSK3B) activity not depending on Ser-9 phosphorylation.
• Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6 coreceptor to downregulate GSK3beta (GSK3B) activity not depending on Ser-9 phosphorylation.
• Missense mutations of the TREX1 gene significantly downregulate its exonucleolytic capacity and result in the accumulation of nucleic acids.
• 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling.
• Next, expression of the PVT1-encoded miRNAs can downregulate tumor suppressor genes, causing tumorigenesis.
• FnrS has been shown to downregulate 32 different mRNAs in Enterobacteria, in 15 of these cases it does so by base-pairing with the mRNA transcript.
• By using a steroid called RU-486 (Mifepristone) to regulate protein kinase A (PKA), they were able to upregulate and downregulate the expression of genes in specific areas like the mushroom bodies, and found that this structure is critical for fly sleep.
• A number of secreted PGRPs have amidase activity that downregulate the Imd pathway by digesting peptidoglycan into short, non-immunogenic fragments.

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