Definition, Meaning & Synonyms | English word MULTIPOTENT

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Definitions of MULTIPOTENT

1. Having the power to do many different things.
2. (biology) Describing a cell that can give rise to a limited number of several different types of cell.

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Examples of Using MULTIPOTENT in a Sentence

• Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
• In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of hematopoietic stem cells that are multipotent and capable of extensive self-renewal.
• Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells.
• The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
• Three of them are named after the known clinical groups: MYCN-amplified, MYCN non-amplified high-risk, and MYCN non-amplified low-risk NBs, while the fourth displays cellular features which resemble multipotent Schwann cell precursors.
• Runx2 is responsible for inducing the differentiation of multipotent mesenchymal cells into immature osteoblasts, as well as activating expression of several key downstream proteins that maintain osteoblast differentiation and bone matrix genes.
• Mesoangioblasts are multipotent stem cells with the potential to progress down the endothelial or mesodermal lineages.
• The centrosome is the most common MTOC for multipotent cells in animals, with differentiated tissues utilising a wide variety of non-centrosomal MTOCs.
• In mice, CD135 is expressed on several hematopoietic (blood) cells, including long- and short-term reconstituting hematopoietic stem cells (HSC) and other progenitors like multipotent progenitors (MPPs) and common lymphoid progenitors (CLP).
• Loss of CD47 allows sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously reprogram to form multipotent embryoid body-like clusters.
• Jade1 expression was detected in extraembryonic ectoderm and trophoblast, which are placental components important for vasculogenesis, as well as in sites enriched with multipotent or tissue-specific progenitors, including neural progenitors(2).
• Phakomatosis pigmentokeratotica is brought on by a multipotent progenitor cell's postzygotic HRAS mutation.
• In 2007, it was confirmed that the amniotic fluid contains a heterogeneous mixture of multipotent cells after it was demonstrated that they were able to differentiate into cells from all three germ layers but they could not form teratomas following implantation into immunodeficient mice.
• Gliogenesis is the generation of non-neuronal glia populations derived from multipotent neural stem cells.
• Other examples include Vasa in multipotent stem cell cluster of Polyascus polygenea buds and stolon, Vasa in auxiliary cells of oyster ovaries, Vasa in non-germ-line lineages in the snail Ilyanassa, Vasa in progenitor mesodermal posterior growth zone of the polychaete annelid Platynereis dumerilii, and Vasa present in non-genetical segments during Oligochaete development.
• Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).
• Haematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent haematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.
• Using lineage tracing of basal cells and luminary mammary gland cells during embryonic development and post-natal development, the Blanpain lab showed that different mammary tissue lineages stem from multipotent embryonic progenitors.
• In 2021, they identified how mutations in mitogen-activated protein kinase pathway genes trigger sensescence in multipotent human hematopoietic progenitor cells that cause multisystem Langerhans Cell Histiocytosis disease by skewing progenitor differentiation towards the mononuclear phagocyte lineage.
• Some of these cells differentiate, creating membranous ossification (bone tissue formation) while some committed osteoprogenitor cells from the periosteum (type of osteogenic tissue) and undifferentiated multipotent MSC from the bone marrow lead to callus formation, which aids in fracture healing.

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